Ventilatory effects of fourth cerebroventricular infusions of morphine-6- or morphine-3-glucuronide in the awake dog.

@article{Pelligrino1989VentilatoryEO,
  title={Ventilatory effects of fourth cerebroventricular infusions of morphine-6- or morphine-3-glucuronide in the awake dog.},
  author={Dale A. Pelligrino and Francis X Riegler and Ronald F. Albrecht},
  journal={Anesthesiology},
  year={1989},
  volume={71 6},
  pages={936-40}
}
The ventilatory effects of morphine-6-glucuronide (M-6-G) and morphine-3-glucuronide (M-3-G) were evaluated in awake dogs (n = 10). A fourth ventricle to cisterna magna perfusion (VCP) system was used for drug administration. This permitted a direct comparison of the dose/ventilatory response characteristics of these morphine metabolites to each other and… CONTINUE READING