Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs.

  title={Ventilatory effects of dexmedetomidine, atipamezole, and isoflurane in dogs.},
  author={David Do Nguyen and I H Abdul-Rasool and Daniel W. Ward and J Hsieh and Daisuke Kobayashi and S Hadlock and Fanny Singer and B. C. Bloor},
  volume={76 4},
Dexmedetomidine (DMED) is a novel alpha 2 adrenergic agonist that has been shown to have potent analgesic and anesthetic sparing effects. This study was designed to investigate the effects of DMED, both alone and combined with isoflurane, on resting ventilation, the hypercapnic response, and the hypoxic response in dogs. When given alone, 1 microgram/kg decreased resting ventilation by 22% but at larger doses (10, 20, and 100 micrograms/kg) resting ventilation increased, doubling at 100… CONTINUE READING

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