Ventilatory acclimatization to moderate hypoxemia in man. The role of spinal fluid (H+).

@article{Dempsey1974VentilatoryAT,
  title={Ventilatory acclimatization to moderate hypoxemia in man. The role of spinal fluid (H+).},
  author={Jerome A. Dempsey and Hubert V. Forster and G A Dopico},
  journal={The Journal of clinical investigation},
  year={1974},
  volume={53 4},
  pages={1091-100}
}
This study has assessed the regulation of arterial blood and cerebrospinal fluid (CSF) pH and thereby their contribution to the control of breathing in normal man during various stages of ventilatory acclimatization to 3,100 m altitude. CSF acid-base status was determined: (a) from measurements of lumbar spinal fluid during steady-state conditions of chronic normoxia (250 m altitude) and at + 8 h and + 3-4 wk of hypobaric hypoxia; and (b) from changes in cerebral venous P(CO2) at + 1 h hypoxic… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Cerebrovascular reactivity is increased with acclimatization to 3,454 m altitude.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2015

Breathing and sleep at high altitude.

Respiratory physiology & neurobiology • 2013
View 1 Excerpt

Effect of high altitude on human auditory brainstem responses.

Indian journal of physiology and pharmacology • 2004
View 1 Excerpt

Clinical acid-base pathophysiology: disorders of plasma anion gap.

Best practice & research. Clinical endocrinology & metabolism • 2003
View 2 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 17 references

The regulation of cerebrospinal fluid pH

V. Fencl
Kidney Int . • 1972

Changes in the electrochemical potential difference for HCO 3 - between blood and cerebrospinal fluid and in cerebrospinal fluid lactate concentration during isocarbic hypoxia

I. Leusen
Acta Physiol . Scand . • 1971

Distribution of H + and HCO 3in cerebral fluids

H. V. Forster, J. A. Dempsey, +4 authors J. Rankin
1971

Quantification of pH regulation in hypercapnia and hypocapnia.

Scandinavian journal of clinical and laboratory investigation • 1971

Regulation of the CSF pH in acute and sustained respiratory acido

L. C. Christianson
Acta Physiol . Scand . • 1971

The chemical control of ventilation

S. Shnider
Acta Physiol . Scand . Suppl . • 1971

The effect of chronic exposure to hypoxia on ventilatory response to CO 2 and hypoxia

H. V. Forster
1971

Similar Papers

Loading similar papers…