Ventilatory Responses to Hypercapnia and Hypoxia in Conscious Cystic Fibrosis Knockout Mice Cftr−/−

@article{Bonora2004VentilatoryRT,
  title={Ventilatory Responses to Hypercapnia and Hypoxia in Conscious Cystic Fibrosis Knockout Mice Cftr−/−},
  author={Monique Bonora and J. -F. Bernaudin and Claude Guernier and Marie Christiane Brahimi-Horn},
  journal={Pediatric Research},
  year={2004},
  volume={55},
  pages={738-746}
}
This study was designed to examine the ventilatory performance and the lung histopathology of cystic fibrosis knockout mice (Cftr−/−) compared with heterozygous (Cftr+/−) or wild-type (Cftr+/+) littermates. Ventilation was recorded in conscious animals using whole-body plethysmography. Tidal volume (VT), respiratory frequency (f), and minute ventilation (VE) were measured during air breathing and in response to various levels of hypercapnia (2, 4, 6, or 8% CO2) or hypoxia (14, 12, 10, or 8% O2… CONTINUE READING