Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome

@article{Kuipers2012VentilatorinducedLI,
  title={Ventilator-induced Lung Injury Is Mediated by the NLRP3 Inflammasome},
  author={M. Kuipers and H. Aslami and J. R. Janczy and K. F. van der Sluijs and A. Vlaar and E. Wolthuis and G. Choi and J. Roelofs and R. Flavell and F. Sutterwala and P. Bresser and J. Leemans and T. van der Poll and M. Schultz and C. Wieland},
  journal={Anesthesiology},
  year={2012},
  volume={116},
  pages={1104–1115}
}
Background: The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. The authors studied the role of the intracellular danger sensor NLRP3 inflammasome. Methods: NLRP3 inflammasome gene expression was analyzed in respiratory epithelial cells and alveolar macrophages obtained from ventilated patients (n = 40). In addition, wild-type and NLRP3 inflammasome deficient mice were randomized to low tidal volume (approximately… Expand
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