Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.

@article{Wilkinson2012VentilatorassociatedPI,
  title={Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.},
  author={Thomas S. Wilkinson and Andrew Conway Morris and Kallirroi Kefala and Cecilia O'kane and Norma R Moore and Nuala Booth and D F Mcauley and Kevin Dhaliwal and Timothy Simon Walsh and Christopher Haslett and Jean-Michel Sallenave and A John Simpson},
  journal={Chest},
  year={2012},
  volume={142 6},
  pages={1425-1432}
}
BACKGROUND Ventilator-associated pneumonia (VAP) is characterized by neutrophils infiltrating the alveolar space. VAP is associated with high mortality, and accurate diagnosis remains difficult. We hypothesized that proteolytic enzymes from neutrophils would be significantly increased and locally produced inhibitors of human neutrophil elastase (HNE) would be decreased in BAL fluid (BALF) from patients with confirmed VAP. We postulated that in suspected VAP, neutrophil proteases in BALF may… CONTINUE READING
Highly Cited
This paper has 32 citations. REVIEW CITATIONS