Ventilation with Negative Airway Pressure Induces a Cytokine Response in Isolated Mouse Lung

@article{Cheng2002VentilationWN,
  title={Ventilation with Negative Airway Pressure Induces a Cytokine Response in Isolated Mouse Lung},
  author={Kuo-Chen Cheng and Haibo Zhang and Chang-Yi Lin and Arthur S Slutsky},
  journal={Anesthesia \& Analgesia},
  year={2002},
  volume={94},
  pages={1577-1582}
}
We tested the hypothesis that, under relatively low tidal volume (Vt) mechanical ventilation, continuing lung decruitment induced by negative end-expiratory pressure (NEEP) would increase the lung cytokine response, potentially contributing to lung injury. Mouse lungs were excised and randomly assigned to one of 3 different ventilatory strategies: 1) the zero end-expiratory pressure group served as a control, 2) the NEEP7 group received a NEEP of −7.5 cm H2O, and 3) the NEEP15 group received a… 

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