Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice.

@article{Wilson2012VentilationW,
  title={Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice.},
  author={Michael Wilson and Brijesh Vipin Patel and Masao Takata},
  journal={Critical care medicine},
  year={2012},
  volume={40 10},
  pages={
          2850-7
        }
}
OBJECTIVE Ventilator-induced lung injury is a crucial determinant of the outcome of mechanically ventilated patients. Increasing numbers of mouse studies have identified numerous pathways and mediators that are modulated by ventilation, but it is conceptually difficult to reconcile these into a single paradigm. There is substantial variability in tidal volumes used in these studies and no certainty about the pathophysiology that such varied models actually represent. This study was designed to… CONTINUE READING
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