Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity.

  title={Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity.},
  author={Roberto Rodr{\'i}guez-Rois{\'i}n and Mitra B. Drakulovic and Diego A Rodr{\'i}guez and Josep Roca and Joan Albert Barber{\`a} and Peter D. Wagner},
  journal={Journal of applied physiology},
  volume={106 6},
Chronic obstructive pulmonary disease (COPD) is characterized by a decline in forced expiratory volume in 1 s (FEV(1)) and, in many advanced patients, by arterial hypoxemia with or without hypercapnia. Spirometric and gas exchange abnormalities have not been found to relate closely, but this may reflect a narrow range of severity in patients studied. Therefore, we assessed the relationship between pulmonary gas exchange and airflow limitation in patients with COPD across the severity spectrum… CONTINUE READING
Highly Cited
This paper has 112 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 46 extracted citations

In silico modeling of oxygen‐enhanced MRI of specific ventilation

Physiological reports • 2018
View 4 Excerpts
Highly Influenced

Detection of lung dysfunction using ventilation and perfusion SPECT in a mouse model of chronic cigarette smoke exposure.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 2013
View 5 Excerpts
Method Support
Highly Influenced

113 Citations

Citations per Year
Semantic Scholar estimates that this publication has 113 citations based on the available data.

See our FAQ for additional information.