Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity.

@article{RodrguezRoisn2009VentilationperfusionIA,
  title={Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity.},
  author={Roberto Rodr{\'i}guez-Rois{\'i}n and Mitra B. Drakulovic and Diego A Rodr{\'i}guez and Josep Roca and Joan Albert Barber{\`a} and Peter D. Wagner},
  journal={Journal of applied physiology},
  year={2009},
  volume={106 6},
  pages={
          1902-8
        }
}
Chronic obstructive pulmonary disease (COPD) is characterized by a decline in forced expiratory volume in 1 s (FEV(1)) and, in many advanced patients, by arterial hypoxemia with or without hypercapnia. Spirometric and gas exchange abnormalities have not been found to relate closely, but this may reflect a narrow range of severity in patients studied. Therefore, we assessed the relationship between pulmonary gas exchange and airflow limitation in patients with COPD across the severity spectrum… CONTINUE READING
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