Ventilation-induced activation of the mitogen-activated protein kinase pathway.

  title={Ventilation-induced activation of the mitogen-activated protein kinase pathway.},
  author={Ulrike Uhlig and Jack Haitsma and Torsten Goldmann and Davey L H Poelma and Burkhard Lachmann and Stefan Uhlig},
  journal={The European respiratory journal},
  volume={20 4},
Mechanical ventilation of patients can be a life-saving treatment, but also imposes additional stress on the lung. Mitogen-activated protein kinases (MAPK) represent a family of protein kinases that become phosphorylated and activated by many different forms of stress. Using Western blot analysis, the present study analysed the effects of high distending pressure ventilation on the activation of the MAPK extracellular signal-related kinases (ERK)-1/2, c-Jun amino-terminal kinases (JNK) and p38… CONTINUE READING