Ventilation heterogeneity in ex-smokers without airflow limitation.

  title={Ventilation heterogeneity in ex-smokers without airflow limitation.},
  author={Damien Pike and Miranda Kirby and Fumin Guo and David G. McCormack and Grace Parraga},
  journal={Academic radiology},
  volume={22 8},
RATIONALE AND OBJECTIVES Hyperpolarized (3)He magnetic resonance imaging (MRI) ventilation abnormalities are visible in ex-smokers without airflow limitation, but the clinical relevance of this is not well-understood. Our objective was to phenotype healthy ex-smokers with normal and abnormally elevated ventilation defect percent (VDP). MATERIALS AND METHODS Sixty ex-smokers without airflow limitation provided written informed consent to (3)He MRI, computed tomography (CT), and pulmonary… CONTINUE READING