Venous thrombosis in inflammatory bowel disease

@article{Srirajaskanthan2005VenousTI,
  title={Venous thrombosis in inflammatory bowel disease},
  author={Raj Srirajaskanthan and Mark Winter and Andrew Frank Muller},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2005},
  volume={17},
  pages={697-700}
}
Patients with inflammatory bowel disease (IBD) have a threefold increased risk of venous thrombosis, a major cause of morbidity and mortality. Although the exact mechanism explaining the initiation of thrombosis remains unclear, it is likely to be a multifactorial process. Reported abnormalities include activation of markers of the coagulation cascade, disturbed fibrinolysis and the activation of platelets. The contribution of thrombophilic disorders such as factor V Leiden, prothrombin gene… 
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Patients with IBD are at considerably increased risk of venothromboembolism and probably of arterial disease, in particular mesenteric ischemia and ischemic heart disease.
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Thromboembolic Events in Patients with Inflammatory Bowel Disease
  • F. Algahtani, Y. Farag, +5 authors M. Shoukri
  • Medicine
    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • 2016
TLDR
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The cases of 4 patients with cerebral vascular involvement are presented, showing the risk of thromboembolism in inflammatory bowel disease and its symptoms may be overlooked.
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This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelia contributing to these conditions.
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