Venous thrombosis in inflammatory bowel disease

@article{Srirajaskanthan2005VenousTI,
  title={Venous thrombosis in inflammatory bowel disease},
  author={Raj Srirajaskanthan and Mark Winter and Andrew Frank Muller},
  journal={European Journal of Gastroenterology \& Hepatology},
  year={2005},
  volume={17},
  pages={697-700}
}
Patients with inflammatory bowel disease (IBD) have a threefold increased risk of venous thrombosis, a major cause of morbidity and mortality. Although the exact mechanism explaining the initiation of thrombosis remains unclear, it is likely to be a multifactorial process. Reported abnormalities include activation of markers of the coagulation cascade, disturbed fibrinolysis and the activation of platelets. The contribution of thrombophilic disorders such as factor V Leiden, prothrombin gene… 
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To evaluate a potential role of procoagulant activity of TF and FXIa in inflammatory bowel disease patients, 80 consecutive IBD patients were studied and inhibitory monoclonal anti-FXI and anti-TF antibodies at a final 0.1 mg/ml concentration were measured and measured clotting time.
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Patients with IBD are at considerably increased risk of venothromboembolism and probably of arterial disease, in particular mesenteric ischemia and ischemic heart disease.
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TLDR
The authors describe two cases of stroke in patients with IBD during periods of increased disease activity, and the literature regarding this devastating complication and the procoagulant state that exists in IBD are reviewed.
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Three cases of portal vein thrombosis occurring in patients with active inflammatory bowel disease are reported and a systematic review based on the clinical literature published on this topic is performed.
Thromboembolic Events in Patients with Inflammatory Bowel Disease
  • F. Algahtani, Y. Farag, M. Shoukri
  • Medicine
    Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
  • 2016
TLDR
In a population with high consanguinity, Thromboembolic events (DVT and PE) had a prevalence of 8% among IBD patients, and positive family history of pulmonary embolism was a predictor of thrombosis.
Cerebral thrombosis in inflammatory bowel disease: a report of four cases.
Thrombotic Storm in a Teenager With Previously Undiagnosed Ulcerative Colitis
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It is concluded that an underlying inflammatory state, such as ulcerative colitis, should be suspected in pediatric patients with venous thrombosis storm, as the first manifestation of an inflammatory bowel disease is extremely rare.
Role of the endothelium in inflammatory bowel diseases.
TLDR
This review examines the roles of the endothelium in the initiation and propagation of IBD pathology and distinctive features of the intestinal endothelia contributing to these conditions.
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References

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