Venous identity is lost but arterial identity is not gained during vein graft adaptation.

@article{Kudo2007VenousII,
  title={Venous identity is lost but arterial identity is not gained during vein graft adaptation.},
  author={Fabio Akimaro Kudo and Akihito Muto and Stephen P. Maloney and Jose Mario Pimiento and Sonia Bergaya and Tamara N. Fitzgerald and Tormod Schumacher Westvik and Jared C. Frattini and Christopher K. Breuer and Charles H. Cha and Toshiya Nishibe and George Tellides and William C Sessa and Alan Dardik},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 7},
  pages={
          1562-71
        }
}
OBJECTIVES Ephrin ligands and Eph receptors are signaling molecules that are differentially expressed on arteries and veins during development. We examined whether Eph-B4, a venous marker, and Ephrin-B2, an arterial marker, are regulated during vein graft adaptation in humans and aged rats. METHODS AND RESULTS Eph-B4 transcripts and immunodetectable protein are downregulated in endothelial and smooth muscle cells of patent vein grafts in both humans and in aged rats, whereas Ephrin-B2… CONTINUE READING

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