Venous and cerebrospinal fluid flow in multiple sclerosis: A case‐control study

@article{Sundstrm2010VenousAC,
  title={Venous and cerebrospinal fluid flow in multiple sclerosis: A case‐control study},
  author={Peter Sundstr{\"o}m and Anders W{\aa}hlin and Khalid Ambarki and Richard Birgander and Anders Eklund and Jan Malm},
  journal={Annals of Neurology},
  year={2010},
  volume={68}
}
The prevailing view on multiple sclerosis etiopathogenesis has been challenged by the suggested new entity chronic cerebrospinal venous insufficiency. To test this hypothesis, we studied 21 relapsing‐remitting multiple sclerosis cases and 20 healthy controls with phase‐contrast magnetic resonance imaging. In addition, in multiple sclerosis cases we performed contrast‐enhanced magnetic resonance angiography. We found no differences regarding internal jugular venous outflow, aqueductal… 
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TLDR
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Extra-cranial venous flow in patients with multiple sclerosis
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TLDR
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TLDR
MS is a complex and devastating disease with imperfect treatment strategies and further research is needed to determine what role, if any, venous insufficiency plays in the course of MS and also the most appropriate treatment course based on those results.
Four-dimensional flow magnetic resonance imaging and ultrasound assessment of cerebrospinal venous flow in multiple sclerosis patients and controls
  • E. Schrauben, S. Kohn, A. Field
  • Medicine, Psychology
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2017
TLDR
Three complementary imaging modalities were used to investigate the chronic cerebrospinal venous insufficiency hypothesis in patients with multiple sclerosis and two age- and sex-matched control groups: healthy volunteers and patients with other neurological diseases.
Multiple sclerosis and chronic cerebrospinal venous insufficiency: a critical review
TLDR
There is inconclusive evidence to support CCSVI as an etiological factor in patients with multiple sclerosis, and endovascular procedures should not be undertaken outside of controlled clinical trials.
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