Venoms, antivenoms and immunotherapy.

@article{Chippaux1998VenomsAA,
  title={Venoms, antivenoms and immunotherapy.},
  author={Jean-Philippe Chippaux and Albert J. van Kuik},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1998},
  volume={36 6},
  pages={
          823-46
        }
}
A century after the discovery of antivenom and despite real progress undertaken in its manufacture, its use remains largely empirical. Recent studies of pharmacokinetics of envenoming permitted improved understanding of immunotherapy. Improved purification of the antivenom by using immunoglobulin fragments has lead to increased tolerance and efficiency of antivenom. The respective advantages and disadvantages of F(ab')2 and F(ab) are discussed in relation to neutralising efficacy and clearance… CONTINUE READING
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