Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells.

@article{dePlater2001VenomFT,
  title={Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells.},
  author={G M de Plater and Peter J. Milburn and R. L. Martin},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 3},
  pages={
          1340-5
        }
}
The platypus (Ornithorhynchus anatinus), a uniquely Australian species, is one of the few living venomous mammals. Although envenomation of humans by many vertebrate and invertebrate species results in pain, this is often not the principal symptom of envenomation. However, platypus envenomation results in an immediate excruciating pain that develops into a very long-lasting hyperalgesia. We have previously shown that the venom contains a C-type natriuretic peptide that causes mast cell… Expand
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Platypus venom: source of novel compounds
TLDR
Five types of proteins and peptides have been isolated and identified from platypus venom, namely: defensin-like peptides (DLPs); Ornithorhynchus venom C-type natriuretic peptide(s) (OvCNPs), and l-to-d-peptide isomerase; and hyaluronidase. Expand
Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells.
TLDR
Heptapeptide 1, which is one of the primary components of the venom fluid, induced a significant increase in [Ca(2+)](i) in IMR-32 cells at 75 microM, the first example of the isolation of the N-terminal linear fragments of CNPs in any mammal. Expand
Platypus Venom: a Review
TLDR
Available literature on O. anatinus venom and venom in other species is reviewed to offer some insight into the evolution and functions of venom components. Expand
Novel venom gene discovery in the platypus
TLDR
83 novel putative platypus venom genes from 13 toxin families, which are homologous to known toxins from a wide range of vertebrates and invertebrates are identified, providing insight into the evolution of mammalian venom. Expand
CHAPTER 43 – Neurotoxic Animal Poisons and Venoms
TLDR
Although there is a vast and fascinating array of aquatic creatures that produce toxins of clinical signifi cance and importance, discussion in this chapter is limited to encounters with land-dwelling creatures. Expand
Tracing Monotreme Venom Evolution in the Genomics Era
TLDR
The physiology of platypus and echidna crural (venom) systems as well as pharmacological and genomic studies of monotreme toxins are reviewed, which synthesize current ideas about the evolution of the venom system. Expand
Platypus venom genes expressed in non-venom tissues
TLDR
The patterns of tissue expression of two venom genes, OvNGF and OvCNP, are reported to provide some insight into the functions of the proteins they produce and to pave the way for further functional and pharmacological studies, which may lead to the development of novel therapeutic agents. Expand
The platypus: evolutionary history, biology, and an uncertain future
TLDR
The evolutionary history, genetics, biology, and ecology of this extraordinary mammal is reviewed, and prevailing threats are highlighted to highlight prevailing threats. Expand
Venomous mammals: a review.
The occurrence of venom in mammals has long been considered of minor importance, but recent fossil discoveries and advances in experimental techniques have cast new light into this subject. Mammalian… Expand
Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.
TLDR
It is shown, in the first expression study on any platypus venom gene, that the OvDLPs are expressed in a greater range of tissues than would be expected for genes with specific venom function, and thus that they may have a wider role than previously suspected. Expand
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References

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TLDR
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The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release.
TLDR
It is found that both ovCNP-39 and the endogenous C-type natriuretic peptide, CNP-22, produce oedema in the rat paw and release histamine from rat peritoneal mast cells. Expand
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TLDR
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TLDR
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