Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells.
@article{dePlater2001VenomFT, title={Venom from the platypus, Ornithorhynchus anatinus, induces a calcium-dependent current in cultured dorsal root ganglion cells.}, author={G M de Plater and Peter J. Milburn and Robert L. Martin}, journal={Journal of neurophysiology}, year={2001}, volume={85 3}, pages={ 1340-5 } }
The platypus (Ornithorhynchus anatinus), a uniquely Australian species, is one of the few living venomous mammals. Although envenomation of humans by many vertebrate and invertebrate species results in pain, this is often not the principal symptom of envenomation. However, platypus envenomation results in an immediate excruciating pain that develops into a very long-lasting hyperalgesia. We have previously shown that the venom contains a C-type natriuretic peptide that causes mast cell…
19 Citations
Platypus venom: source of novel compounds
- Biology, Chemistry
- 2009
Five types of proteins and peptides have been isolated and identified from platypus venom, namely: defensin-like peptides (DLPs); Ornithorhynchus venom C-type natriuretic peptide(s) (OvCNPs), and l-to-d-peptide isomerase; and hyaluronidase.
Duck-billed platypus venom peptides induce Ca2+ influx in neuroblastoma cells.
- Biology, ChemistryJournal of the American Chemical Society
- 2009
Heptapeptide 1, which is one of the primary components of the venom fluid, induced a significant increase in [Ca(2+)](i) in IMR-32 cells at 75 microM, the first example of the isolation of the N-terminal linear fragments of CNPs in any mammal.
Platypus Venom: a Review
- Biology
- 2007
Available literature on O. anatinus venom and venom in other species is reviewed to offer some insight into the evolution and functions of venom components.
Novel venom gene discovery in the platypus
- BiologyGenome Biology
- 2010
83 novel putative platypus venom genes from 13 toxin families, which are homologous to known toxins from a wide range of vertebrates and invertebrates are identified, providing insight into the evolution of mammalian venom.
Tracing Monotreme Venom Evolution in the Genomics Era
- BiologyToxins
- 2014
The physiology of platypus and echidna crural (venom) systems as well as pharmacological and genomic studies of monotreme toxins are reviewed, which synthesize current ideas about the evolution of the venom system.
Platypus venom genes expressed in non-venom tissues
- Biology, Chemistry
- 2009
The patterns of tissue expression of two venom genes, OvNGF and OvCNP, are reported to provide some insight into the functions of the proteins they produce and to pave the way for further functional and pharmacological studies, which may lead to the development of novel therapeutic agents.
The platypus: evolutionary history, biology, and an uncertain future
- Environmental ScienceJournal of mammalogy
- 2019
The evolutionary history, genetics, biology, and ecology of this extraordinary mammal is reviewed, and prevailing threats are highlighted to highlight prevailing threats.
Venomous mammals: a review.
- BiologyToxicon : official journal of the International Society on Toxinology
- 2012
Expression patterns of platypus defensin and related venom genes across a range of tissue types reveal the possibility of broader functions for OvDLPs than previously suspected.
- BiologyToxicon : official journal of the International Society on Toxinology
- 2008
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