Venom Ontogeny in the Mexican Lance-Headed Rattlesnake (Crotalus polystictus)

@article{Mackessy2018VenomOI,
  title={Venom Ontogeny in the Mexican Lance-Headed Rattlesnake (Crotalus polystictus)},
  author={Stephen P. Mackessy and Jamie Leroy and Estrella Moci{\~n}o-Deloya and Kirk Setser and Robert W. Bryson and Anthony J. Saviola},
  journal={Toxins},
  year={2018},
  volume={10}
}
As trophic adaptations, rattlesnake venoms can vary in composition depending on several intrinsic and extrinsic factors. Ontogenetic changes in venom composition have been documented for numerous species, but little is known of the potential age-related changes in many rattlesnake species found in México. In the current study, venom samples collected from adult and neonate Crotalus polystictus from Estado de México were subjected to enzymatic and electrophoretic analyses, toxicity assays (LD50… 

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References

SHOWING 1-10 OF 96 REFERENCES
Venom ontogeny in the Pacific rattlesnakes Crotalus viridis helleri and C. v. oreganus
TLDR
Analysis of gut contents of museum specimens showed that lizards constitute a major fraction of prey taken by juvenile rattlesnakes, aiding in the digestion of prey in a thermally variable environment, which facilitates efficient handling of lizards and young rodents.
Biological and Proteolytic Variation in the Venom of Crotalus scutulatus scutulatus from Mexico
TLDR
The results suggest that venoms containing Mojave toxin and venom lacking this toxin are distributed in the northwest and southeast portions of the distribution in Mexico, respectively, while an intergradation in the middle of both zones is present.
Venom of the Brown Treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity.
Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.
TLDR
The increased concentration of the neurotoxins crotoxin and crotamine in South American rattlesnake venoms strongly argues that the gain of neurotoxicity and lethal venom activities to mammals may have represented the key axis along which overall venom toxicity has evolved during Crotalus durissus invasion of South America.
Ontogenetic variations in the venom proteome of the Amazonian snake Bothrops atrox
TLDR
The analysis of B. atrox samples from specimens of different ages by 2-DE and mass spectrometry suggested that venom proteome alters upon ontogenetic development, which provides insight into the molecular basis of the relation between symptomatology of snakebite accidents in humans and the venom composition.
The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus)
TLDR
Adult and juvenile venom-gland transcriptomes for a species with known ontogenetic venom variation were equally effective at individually providing a full characterization of the venom genes of a species but that any particular individual was likely to lack several toxins in their transcriptome.
Venom Composition in Rattlesnakes: Trends and Biological Significance
TLDR
Rattlesnakes represent an excellent group for studying venom evolution in squamates, and many unanswered questions remain, particularly concerning many Mexican rattlesnake taxa and with regard to comparative toxicity of venom component isoforms to native prey species.
Integrated Venomics and Venom Gland Transcriptome Analysis of Juvenile and Adult Mexican Rattlesnakes Crotalus simus, C. tzabcan, and C. culminatus Revealed miRNA-modulated Ontogenetic Shifts.
TLDR
The results support the hypothesis that alterations of the distribution of miRNAs, modulating the translational activity of venom gland toxin-encoding mRNAs in response to an external cue, may contribute to the mechanism generating adaptive venom variability.
...
...