Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.

@article{Russmann2001VenoocclusiveDN,
  title={Veno-occlusive disease, nodular regenerative hyperplasia and hepatocellular carcinoma after azathioprine treatment in a patient with ulcerative colitis.},
  author={Stefan Russmann and Arthur Zimmermann and Stephan Kr{\"a}henb{\"u}hl and Beatrice E. Kern and Juerg Reichen},
  journal={European journal of gastroenterology & hepatology},
  year={2001},
  volume={13 3},
  pages={287-90}
}
We report the case of a 66-year-old male with ulcerative colitis diagnosed in 1987, who had been treated with azathioprine (AZA) for the past two years (average dose about 1.6 mg/kg/day). In May 1999 he presented with painless jaundice, fatigue and recent weight loss. Cholestatic enzymes were elevated, alpha-fetoprotein was normal and hepatitis B/C serology negative. After diagnosis of veno-occlusive disease (VOD) and hepatocellular carcinoma (HCC) via biopsy, tumour resection was performed… CONTINUE READING