Venlafaxine versus lithium monotherapy of rapid and non-rapid cycling patients with bipolar II major depressive episode: a randomized, parallel group, open-label trial.

@article{Amsterdam2009VenlafaxineVL,
  title={Venlafaxine versus lithium monotherapy of rapid and non-rapid cycling patients with bipolar II major depressive episode: a randomized, parallel group, open-label trial.},
  author={Jay D. Amsterdam and Chia-Hao Wang and Michelle Shwarz and Justine Shults},
  journal={Journal of affective disorders},
  year={2009},
  volume={112 1-3},
  pages={219-30}
}
BACKGROUND There is a paucity of controlled clinical data on the best initial therapy for treating patients with bipolar type II (BP II) major depressive episode (MDE). In this analysis, we examined the safety and antidepressant efficacy of short-term venlafaxine versus lithium monotherapy in rapid and non-rapid cycling patients with BP II MDE. We hypothesized that lithium would have superior efficacy to venlafaxine, with fewer syndromal and sub-syndromal hypomanic and mixed mood conversions in… CONTINUE READING
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