Venlafaxine serum levels and CYP2D6 genotype.

@article{Veefkind2000VenlafaxineSL,
  title={Venlafaxine serum levels and CYP2D6 genotype.},
  author={Adriaan H. Veefkind and P. M. Judith Haffmans and Erik Hoencamp},
  journal={Therapeutic drug monitoring},
  year={2000},
  volume={22 2},
  pages={
          202-8
        }
}
Thirty-three patients with depression treated with 225 mg venlafaxine were genotyped for the polymorphic enzyme, debrisoquine 4-hydroxylase (CYP2D6). The relationship between drug and metabolite levels and between genotype and clinical response were investigated. Although the number of responders in this study is insufficient for definite conclusions to be drawn, a target therapeutic concentration ranging from 195-400 microg/L for the sum of venlafaxine and O-desmethylvenlafaxine is suggested… CONTINUE READING
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