Venlafaxine loaded chitosan NPs for brain targeting: pharmacokinetic and pharmacodynamic evaluation.

@article{Haque2012VenlafaxineLC,
  title={Venlafaxine loaded chitosan NPs for brain targeting: pharmacokinetic and pharmacodynamic evaluation.},
  author={Shadabul Haque and Shadab and Mohammad Fazil and M. V. Jagannadha Kumar and Jasjeet Kaur Sahni and Javed Ali and Sanjula Baboota},
  journal={Carbohydrate polymers},
  year={2012},
  volume={89 1},
  pages={72-9}
}
The purpose of the present investigation was to prepare venlafaxine (VLF) loaded chitosan nanoparticles (NPs) to enhance the uptake of VLF to brain via intranasal (i.n.) delivery. VLF loaded chitosan NPs were prepared and characterized for particle size, size distribution, zeta potential, encapsulation efficiency and in vitro drug release. In order to investigate the localization of chitosan NPs in brain and other organs qualitatively confocal laser scanning microscopy technique was carried out… CONTINUE READING
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BBB transport using MDR 1 A ( − / − ) and wild - type mice . Total brain versus microdialysis concentration profiles of Rhodamine123

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