Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo.

@article{Gur1999VenlafaxineAA,
  title={Venlafaxine: acute and chronic effects on 5-hydroxytryptamine levels in rat brain in vivo.},
  author={Eitan Gur and Eliyahu Dremencov and Bernard Lerer and Michael E. Newman},
  journal={European journal of pharmacology},
  year={1999},
  volume={372 1},
  pages={17-24}
}
Venlafaxine is a dual serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake inhibitor which has been claimed to have an onset of antidepressant action which is faster than for other comparable drugs. The effects of venlafaxine on brain 5-HT levels in vivo have not yet been examined. Acute administration of venlafaxine to rats by i.p. injection resulted in dose-dependent increases in cortical and hippocampal 5-HT levels, as measured by in vivo microdialysis, over the range 5-20 mg/kg… CONTINUE READING

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