Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-tumor Immunity to the ‘Self’ tumor-associated antigen, neu in a Rat Mammary Tumor Model

@article{Nelson2003VenezuelanEE,
  title={Venezuelan Equine Encephalitis Replicon Immunization Overcomes Intrinsic Tolerance and Elicits Effective Anti-tumor Immunity to the ‘Self’ tumor-associated antigen, neu in a Rat Mammary Tumor Model},
  author={Edward L Nelson and DaRue Prieto and Terri G. Alexander and Peter Pushko and Loreen A. Lofts and Jonathan O. Rayner and Kurt I. Kamrud and Bolyn H Fralish and Jonathan F. Smith},
  journal={Breast Cancer Research and Treatment},
  year={2003},
  volume={82},
  pages={169-183}
}
Many tumor-associated antigens (TAAs) represent ‘self’ antigens and as such, are subject to the constraints of immunologic tolerance. There are significant barriers to eliciting anti-tumor immune responses of sufficient magnitude. We have taken advantage of a Venezuelan equine encephalitis-derived alphavirus replicon vector system with documented in vivo tropism for immune system dendritic cells. We have overcome the intrinsic tolerance to the ‘self’ TAA rat neu and elicited an effective anti… CONTINUE READING
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  • JP Gardner, G Donovan, +7 authors WC O
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