Vemurafenib resistance reprograms melanoma cells towards glutamine dependence

  title={Vemurafenib resistance reprograms melanoma cells towards glutamine dependence},
  author={Jenny E Hernandez-Davies and Thai Q. Tran and Michael R. Reid and K. Rosales and X. Lowman and Min Pan and Gatien Moriceau and Y. Yang and J. Wu and R. Lo and M. Kong},
  journal={Journal of Translational Medicine},
  • Jenny E Hernandez-Davies, Thai Q. Tran, +8 authors M. Kong
  • Published 2015
  • Biology, Medicine
  • Journal of Translational Medicine
  • BackgroundV600BRAF mutations drive approximately 50% of metastatic melanoma which can be therapeutically targeted by BRAF inhibitors (BRAFi) and, based on resistance mechanisms, the combination of BRAF and MEK inhibitors (BRAFi + MEKi). Although the combination therapy has been shown to provide superior clinical benefits, acquired resistance is still prevalent and limits the overall survival benefits. Recent work has shown that oncogenic changes can lead to alterations in tumor cell metabolism… CONTINUE READING
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