Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.

@article{Du2004VelvetAD,
  title={Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice.},
  author={Xin Du and Koichi Tabeta and Kasper Hoebe and Haiquan Liu and Navjiwan Mann and Suzanne Mudd and Karine Crozat and Sosathya Sovath and Xiaohua Gong and Bruce Beutler},
  journal={Genetics},
  year={2004},
  volume={166 1},
  pages={331-40}
}
In the course of a large-scale program of ENU mutagenesis, we isolated a dominant mutation, called Velvet. The mutation was found to be uniformly lethal to homozygotes, which do not survive E13.5. Mice heterozygous for the Velvet mutation are born with eyelids open and demonstrate a wavy coat and curly vibrissae. The mutation was mapped to the proximal end of chromosome 11 by genome-wide linkage analysis. On 249 meioses, the locus was confined to a 2.7-Mb region, which included the epidermal… CONTINUE READING