Velamentous umbilical cord insertion may be suspected from maternal serum α‐fetoprotein and hCG

  title={Velamentous umbilical cord insertion may be suspected from maternal serum $\alpha$‐fetoprotein and hCG},
  author={Seppo Heinonen and Markku Ryyn{\"a}nen and Pertti P Kirkinen and Seppo Saarikoski},
  journal={BJOG: An International Journal of Obstetrics \& Gynaecology},
Objective Patients with unexplained elevations in second trimester maternal serum α‐fetoprotein or human chorionic gonadotrophin (hCG) concentrations are at increased risk as regards a variety of pregnancy complications and adverse perinatal outcomes. Evidence suggests that elevated α‐fetoprotein and hCG concentrations may, in some case, be sensitive indicators of underlying placental pathology, either vascular or inflammatory in nature. The present study was carried out to compare these… 
Clinical follow‐up of high mid‐trimester maternal serum intact human chorionic gonadotrophin concentrations in singleton pregnancies
Mid‐trimester biochemical screening of 38143 pregnancies in south‐east Scotland revealed 127 cases (0·34 per cent) in which the maternal serum (MS) intact human chorionic gonadotrophin (hCG)
Mid-Trimester Maternal Serum hCG and Alpha Fetal Protein Levels: Clinical Significance and Prediction of Adverse Pregnancy Outcome
Combined mid-trimester elevation in maternal serum hCG and AFP levels suggest a more complex type of placental pathology, which may allow us to identify women with increased risk to develop severe placental insufficiency and pregnancy complications.
Phenotypic Diversity and Genetic Epidemiology of Placental Abruption
It is shown that the outcome of PA is still poor, as the perinatal mortality rate was 10% and 59.4% of the newborns were premature, and the obstetric prognosis after PA was comparable to that of the general obstetric population if there was no recurrence of PA.
Prediction of Pre-Eclampsia in Second Trimester by Estimating the Spot Urinary Protein Creatinine Ratio
Evaluating the spot urinary protein creatinine ratio in pregnant women from 13 to 20 weeks of gestation to assess its usefulness in predicting their risk of developing pre-eclampsia subsequently found it to be useful.
Prevalence, Risk Factors and Outcomes of Velamentous and Marginal Cord Insertions: A Population-Based Study of 634,741 Pregnancies
The two conditions shared risk factors; twin gestation and pregnancies conceived with the aid of assisted reproductive technology were the most important, while bleeding in pregnancy, advanced maternal age, maternal chronic disease, female foetus and previous pregnancy with anomalous cord insertion were other risk factors.
Abdominal wall and umbilical cord anomalies.
Relationship between placental morphology and histological findings in an unselected population near term
The macroscopic morphological features of the placenta cannot predict the presence or absence of the histological placental lesions, nor are these lesions in general associated with differences in cord centrality, placental eccentricity or cord coiling.
Women's experiences of prenatal serum screening.
The significant negative psychosocial effects of serum screening should be taken into account by caregivers when deciding whether and how to institutionalize these tests as part of antenatal care.
Evaluation of chemical tests for fetal bleeding from vasa previa


Relationship Between Placental Shape, Cord Insertion, Lobes and Gestational Outcome
A paucity of lobes was associated with extrachorial placenta, marginal cord insertion, pre‐eclampsia, gestational age less than 38 weeks and small for Gestational age infants.
  • J. Rolschau
  • Medicine
    Acta obstetricia et gynecologica Scandinavica
  • 1978
Some disorders of the umbilical cord—Single umbilical artery, oedema of the cord, battledore insertion and velamentous insertion—have been examined in a prospectively randomized material. The
Elevated second trimester maternal serum beta-HCG concentrations and subsequent adverse pregnancy outcome.
Elevated mid-trimester maternal serum beta-HCG may be an independent risk factor for subsequent adverse pregnancy outcomes and is reviewed retrospectively the pregnancy outcomes among women with markedly elevated midtrimester beta- HCG in the prenatal screening program.
Prenatal screening for Down's syndrome with use of maternal serum markers.
Measuring serum alpha-fetoprotein, chorionic gonadotropin, and estriol is more effective in screening for fetal Down's syndrome than measuring maternal serumalpha- fetoprotein alone and can readily be incorporated into existing prenatal screening programs.
The positive association among women with low AFP levels was substantially reduced when the analysis was restricted to women who had spontaneous labours and it seems that this minor positive association arises mainly because women in whom gestation is over‐estimated tend to have both a low AFP and, later, an apparently prolonged pregnancy leading to the elective delivery of an infant who is, in fact, born early.
Velamentous insertion of the umbilical cord.
From 54 cases reported in the literature since 1952, it appears that the fetal mortality is likely to remain very high in this condition, at least for the foreseeable future.
Maternal serum screening for Down's syndrome in early pregnancy.
The new screening method would detect over 60% of affected pregnancies, more than double that achievable with the same amniocentesis rate in existing programmes, and could reduce the number of children born with Down's syndrome in the United Kingdom from about 900 a year to about 350 a year.
Clinical significance and sonographic diagnosis of velamentous umbilical cord insertion.
Pregnancy outcomes in VCI patients with 77 singleton gestations were compared with a control group of 15,865 patients and, in contrast to the existing literature, multiparity and prior cesarean section deliveries were not increased in pregnancies with VCI.