Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified.

@article{Agarwal2004VeinPW,
  title={Vein pretreatment with magnesium sulfate to prevent pain on injection of propofol is not justified.},
  author={Anil L. Agarwal and Sanjay Dhiraj and Mehdi Raza and Ravinder Kumar Pandey and Chandra Kant Pandey and Prabhat K. Singh and Uttam Singh and Devendra Gupta},
  journal={Canadian journal of anaesthesia = Journal canadien d'anesthesie},
  year={2004},
  volume={51 2},
  pages={130-3}
}
PURPOSE Propofol produces anesthesia with rapid recovery. However, it causes pain or discomfort on injection. A number of techniques have been tried for minimizing propofol-induced pain with variable results. We have compared the efficacy of magnesium and lidocaine for the prevention of propofol induced pain. METHODS Three hundred ASA I and II adults undergoing elective surgery were randomly assigned into three groups of 100 each. Group I received magnesium sulfate 1 g, Group II received… CONTINUE READING

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Effects and safety of magnesium sulfate on propofol-induced injection pain, a meta-analysis of randomized controlled trials.

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