Vehicle influence on permeation through intact and compromised skin.

  title={Vehicle influence on permeation through intact and compromised skin.},
  author={Meera Gujjar and Ajay K. Banga},
  journal={International journal of pharmaceutics},
  volume={472 1-2},
The purpose of this study was to compare the transdermal permeation of a model compound, diclofenac diethylamine, from a hydrophilic and lipophilic vehicle across in vitro models simulating compromised skin. Mineral oil served as a lipophilic vehicle while 10mM phosphate buffered saline served as a hydrophilic vehicle. Compromised skin was simulated by tape stripping, delipidization, or microneedle application and compared with intact skin as a control. Transepidermal water loss was measured to… CONTINUE READING

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The correlation between transepidermal water loss and percutaneous absorption: an overview.

Journal of controlled release : official journal of the Controlled Release Society • 2005
View 3 Excerpts
Highly Influenced

Correlation of transepidermal water loss with skin barrier properties in vitro: comparison of three evaporimeters.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging • 2010
View 2 Excerpts

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