Vehicle and positive control values from the in vivo rodent comet assay and biomonitoring studies using human lymphocytes: historical database and influence of technical aspects.

Abstract

There is increased interest in the in vivo comet assay in rodents as a follow-up approach for determining the biological relevance of chemicals that are genotoxic in in vitro assays. This is partly because, unlike other assays, DNA damage can be assessed in this assay in virtually any tissue. Since background levels of DNA damage can vary with the species… (More)
DOI: 10.1002/em.21881

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@article{Pant2014VehicleAP, title={Vehicle and positive control values from the in vivo rodent comet assay and biomonitoring studies using human lymphocytes: historical database and influence of technical aspects.}, author={Kamala Pant and Sandra S Springer and Shannon Wilson Bruce and Timothy E Lawlor and Nadine Hewitt and Marilyn J. Aardema}, journal={Environmental and molecular mutagenesis}, year={2014}, volume={55 8}, pages={633-42} }