Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.

@article{Ling2019VedolizumabmediatedI,
  title={Vedolizumab-mediated integrin $\alpha$4$\beta$7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.},
  author={Lijun Ling and Tongjin Wu and Kelvin Kai-Wang To and Ka-wai Cheung and Kathy Oi Lan Lui and Mengyue Niu and Ka Shing Lam and Chi Chi Wang and Jiatao Li and Hui Wang and Kwok Yung Yuen and Zhiwei Chen},
  journal={AIDS},
  year={2019},
  volume={33 4},
  pages={
          F1-F12
        }
}
OBJECTIVE The combined combination antiretroviral therapy (cART) and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control simian immunodeficiency virus (SIV) rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would have similar effects in controlling live HIV-1 infection in humanized mice. DESIGN AND METHODS The integrin α4β7 blockade by VDZ was evaluated on human primary… 
α4β7high CD4+ T cells are prone to be infected by HIV‐1 and associated with HIV‐1 disease progression
TLDR
To investigate the characteristics of β7high CD4+ T cells during HIV‐1 infection and the relationship between β7 high T cells and HIV‐ 1 disease progress, a large number of subjects were randomly selected to undergo cell reprograming.
Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV‐infected rhesus macaques
  • W. Ziani, Jiasheng Shao, Huanbin Xu
  • Biology, Medicine
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2021
TLDR
The findings suggest that integrin blockade alone fails to effectively control viral infection, replication, dissemination, and reservoir establishment in HIV‐1/SIV infection.
Search for antiviral functions of potentially protective antibodies against V2 region of HIV-1
  • M. Gorny
  • Biology
    Human vaccines & immunotherapeutics
  • 2020
TLDR
Observations suggest that V2 Abs may not control SHIV infection in rhesus macaques and that V 2 Abs may instead be a surrogate marker of other protective immune responses.
Integrin α4β7 in HIV‐1 infection: A critical review
TLDR
The jury is still out on the role of α4β7 in HIV‐1 infection, and conflicting results have been reported on the effects of the same antibody, in combination with ART, during the early chronic phase of SIV infection.
Vedolizumab use and the associations between α4β7 expression and HIV reservoir in the gut during treated primary HIV infection.
TLDR
Results from two multicentre, double-blind, randomised, noninferiority, phase 3 trials on the use of antiretroviral drugs for treatment and prevention of HIV infection in adults in adults aged 50 years or older in Spain are published.
Anti-trafficking agents in the treatment of inflammatory bowel disease.
TLDR
A class of therapeutics with growing importance in the field of inflammatory bowel diseases that specifically inhibit steps of immune cell trafficking that can be considered an indispensable column of IBD therapy is described.
Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis
TLDR
The results of the current study will contribute to the understanding of the dynamics of α4β7 expression pattern on T cells in HIV and UC and will be useful for future studies investigating VDZ as possible HIV cure strategy.

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