Vedolizumab-mediated integrin α4β7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.

@article{Ling2019VedolizumabmediatedI,
  title={Vedolizumab-mediated integrin $\alpha$4$\beta$7 blockade does not control HIV-1SF162 rebound after combination antiretroviral therapy interruption in humanized mice.},
  author={Lijun Ling and Tongjin Wu and Kelvin Kai-Wang To and Ka-wai Cheung and Kathy Oi Lan Lui and Mengyue Niu and Ka Shing Lam and Chi Chi Wang and Jiatao Li and Hui Wang and Kwok Yung Yuen and Zhiwei Chen},
  journal={AIDS},
  year={2019},
  volume={33 4},
  pages={
          F1-F12
        }
}
OBJECTIVE The combined combination antiretroviral therapy (cART) and anti-α4β7 RM-Act-1 antibody therapy allows macaques to durably control simian immunodeficiency virus (SIV) rebound after withdrawal of the interventions. Here, we aimed to investigate whether vedolizumab (VDZ), a clinical-grade humanized anti-α4β7 antibody, would have similar effects in controlling live HIV-1 infection in humanized mice. DESIGN AND METHODS The integrin α4β7 blockade by VDZ was evaluated on human primary… Expand
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