Vectors based on reducible polycations facilitate intracellular release of nucleic acids.

@article{Read2003VectorsBO,
  title={Vectors based on reducible polycations facilitate intracellular release of nucleic acids.},
  author={Martin L Read and Kathryn Bremner and David Oupick{\'y} and Nicola K. Green and Peter F. Searle and Leonard W Seymour},
  journal={The journal of gene medicine},
  year={2003},
  volume={5 3},
  pages={
          232-45
        }
}
BACKGROUND Inefficient intracellular delivery of nucleic acids limits the therapeutic usefulness of synthetic vectors such as poly(L-lysine) (PLL)/DNA polyplexes. This article reports on the characterisation of a new type of synthetic vector based on a linear reducible polycation (RPC) that can be cleaved by the intracellular environment to facilitate release of nucleic acids. METHODS RPCs of molecular weight (mwt) 45 and 187 kDa were prepared by oxidative polycondensation of the peptide Cys… CONTINUE READING
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