Vectorial transport and folding of an autotransporter virulence protein during outer membrane secretion.

@article{Junker2009VectorialTA,
  title={Vectorial transport and folding of an autotransporter virulence protein during outer membrane secretion.},
  author={Mirco Junker and Richard N. Besingi and Patricia L. Clark},
  journal={Molecular microbiology},
  year={2009},
  volume={71 5},
  pages={1323-32}
}
Autotransporter (AT) proteins are a large and diverse family of extracellular virulence proteins from Gram-negative bacteria, characterized by a central beta-helix domain within the mature virulence protein. It is not clear how these proteins cross the outer membrane (OM) quickly and efficiently, without assistance from an external energy source such as ATP or a proton gradient. Conflicting results in the literature have led to several proposed mechanisms for AT OM secretion, including a… CONTINUE READING
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