Vector Transmission of Leishmania Abrogates Vaccine-Induced Protective Immunity

@inproceedings{Peters2009VectorTO,
  title={Vector Transmission of Leishmania Abrogates Vaccine-Induced Protective Immunity},
  author={Nathan C Peters and Nicola Kimblin and Nagila Secundino and Shaden Kamhawi and Phillip G. Lawyer and David L Sacks},
  booktitle={PLoS pathogens},
  year={2009}
}
Numerous experimental vaccines have been developed to protect against the cutaneous and visceral forms of leishmaniasis caused by infection with the obligate intracellular protozoan Leishmania, but a human vaccine still does not exist. Remarkably, the efficacy of anti-Leishmania vaccines has never been fully evaluated under experimental conditions following natural vector transmission by infected sand fly bite. The only immunization strategy known to protect humans against natural exposure is… CONTINUE READING
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