Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans.

@article{Fenoglio2009Vdelta1TL,
  title={Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans.},
  author={Daniela Fenoglio and Alessandro Poggi and Silvia Catellani and Florinda Battaglia and Alessandra Ferrera and Maurizio Setti and Giuseppe Murdaca and Maria Raffaella Zocchi},
  journal={Blood},
  year={2009},
  volume={113 26},
  pages={6611-8}
}
In early HIV-1 infection, Vdelta1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1-infected patients ex vivo-isolated Vdelta1 T cells display cytoplasmic interferon-gamma (IFN-gamma). Interestingly, these cells coexpress cytoplasmic interleukin-17 (IL-17), and bear the CD27 surface marker of the memory T-cell subset. Vdelta1 T cells, isolated… CONTINUE READING

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