Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.

@article{Poggi2004Vdelta1TL,
  title={Vdelta1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid.},
  author={Alessandro Poggi and Claudia Venturino and Silvia Catellani and Marino Clavio and Maurizio Miglino and Marco Gobbi and Alexander Steinle and Paolo Ghia and Stefania Stella and Federico Caligaris-Cappio and Maria Raffaella Zocchi},
  journal={Cancer research},
  year={2004},
  volume={64 24},
  pages={9172-9}
}
We analyzed 38 untreated patients with chronic lymphocytic leukemia of B-cell type (B-CLL): 24 low-, 8 intermediate-, and 6 high-risk stage. In 15 patients (13 low risk and 2 intermediate risk), circulating Vdelta1 T lymphocytes were significantly increased (100 to 300 cells/muL) compared with most intermediate, all high-risk stage, and 15 healthy donors (50 to 100 cells/muL). We studied these Vdelta1 T lymphocytes and observed that they proliferated in vitro and produced tumor necrosis factor… CONTINUE READING

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