Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice.

@article{Tagawa2004Vdelta1GT,
  title={Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice.},
  author={Tetsuzo Tagawa and Hitoshi Nishimura and Toshiki Yajima and Hiromitsu Hara and Kenji Kishihara and Goro Matsuzaki and Ichiro Yoshino and Yoshihiko Maehara and Yasunobu Yoshikai},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={5156-64}
}
An influx of neutrophils followed a short time later by an influx of macrophages to the infected site plays a key role in innate immunity against Escherichia coli infection. We found in this study that Vdelta1-/- mice exhibited impaired accumulation of peritoneal macrophages but not neutrophils and delayed bacterial clearance after i.p. inoculation with E. coli. Peritoneal gammadelta T cells from E. coli-infected wild-type mice produced CCL3/MIP-1alpha and CCL5/RANTES in response to gammadelta… CONTINUE READING