Vbeta-restricted T cell adherence to endothelial cells: a mechanism for superantigen-dependent vascular injury.

@article{Brogan2004VbetarestrictedTC,
  title={Vbeta-restricted T cell adherence to endothelial cells: a mechanism for superantigen-dependent vascular injury.},
  author={P. A. Brogan and Vanita Shah and Nigel Klein and Michael J. Dillon},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 2},
  pages={589-97}
}
OBJECTIVE To investigate the potential for endothelial cells to operate as superantigen-presenting cells for T cells and the potential for such an interaction to cause endothelial cell activation and injury. METHODS Class II major histocompatibility complex (MHC)-positive human umbilical vein endothelial cells (HUVECs) were cocultured for 4 hours with purified T cells and the superantigens staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin 1 (TSST-1). After staining with… CONTINUE READING