Vaxfectin-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge.

@article{Jimenez2007VaxfectinformulatedID,
  title={Vaxfectin-formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge.},
  author={Gretchen S. Jimenez and Rodrick Planchon and Qun Wei and Denis Rusalov and Andrew J. Geall and Joel D Enas and Peggy A Lalor and Vicky L Leamy and Ruth Vahle and Catherine J. Luke and Alain Rolland and David C Kaslow and Larry R Smith},
  journal={Human vaccines},
  year={2007},
  volume={3 5},
  pages={157-64}
}
Next generation influenza vaccines containing conserved antigens may enhance immunity against seasonal or pandemic influenza virus strains. Using a plasmid DNA (pDNA)-based vaccine approach, we systematically tested combinations of NP, M1, and M2 antigens derived from consensus sequences for protection against lethal influenza challenge and compared formulations for adjuvanting low pDNA vaccine doses. The highest level of protection at the lowest pDNA doses was provided by Vaxfectin-formulated… CONTINUE READING

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