Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization.

@article{Reyes2001VaxfectinEA,
  title={Vaxfectin enhances antigen specific antibody titers and maintains Th1 type immune responses to plasmid DNA immunization.},
  author={Lilian Reyes and Jukka Hartikka and Vesselina Bozoukova and Loretta Sukhu and Wakako Nishioka and Gita Singh and Marilyn Ferrari and Joel D Enas and Carl J Wheeler and Marston Manthorpe and Mary K Wloch},
  journal={Vaccine},
  year={2001},
  volume={19 27},
  pages={3778-86}
}
Antigen specific immune responses were characterized after intramuscular immunization of BALB/c mice with 5 antigen encoding plasmid DNAs (pDNAs) complexed with Vaxfectin, a cationic lipid formulation. Vaxfectin increased IgG titers for all of the antigens with no effect on the CTL responses to the 2 antigens for which CTL assays were performed. Both antigen specific IgG1 and IgG2a were increased, although IgG2a remained greater than IgG1. Furthermore, Vaxfectin had no effect on IFN-gamma or IL… CONTINUE READING
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