Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.

@article{Lin2012Vav3rac1SR,
  title={Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.},
  author={Kai-Ti Lin and Jianli Gong and C. Li and Te-Hsuan Jang and Wen-ling Chen and Huei-Jane Chen and L Wang},
  journal={Cancer research},
  year={2012},
  volume={72 12},
  pages={3000-9}
}
Prostate cancer remains the second leading cause of cancer death in men in the Western world. Yet current therapies do not significantly improve the long-term survival of patients with distant metastasis. In this study, we investigated the role of the guanine nucleotide exchange factor Vav3 in prostate cancer progression and metastasis and found that Vav3 expression correlated positively with prostate cancer cell migration and invasion. Stimulation of the receptor tyrosine kinase EphA2 by… CONTINUE READING