Vav3 is regulated during the cell cycle and effects cell division.

  title={Vav3 is regulated during the cell cycle and effects cell division.},
  author={Keiko Fujikawa and Yoshiro Inoue and Masaharu Sakai and Yoshikazu Koyama and Shinzo Nishi and Ryo Funada and Frederick W Alt and Wojciech Swat},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 7},
Vav3 is a member of the family of guanine nucleotide exchange factors implicated in the regulation of Rho GTPases. Although the exact in vivo function of Vav3 is unknown, evidence from several studies indicates a role distinct from Vav2 or Vav1. Here we report that the expression of Vav3 is regulated during the cell cycle. Strikingly, Vav3 was transiently up-regulated in HeLa cells during mitosis, whereas enforced expression of Vav3 perturbed cytokinesis and led to the appearance of… CONTINUE READING

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