Vav2 is an activator of Cdc42, Rac1, and RhoA.

  title={Vav2 is an activator of Cdc42, Rac1, and RhoA.},
  author={Koji Abe and Kent L. Rossman and Bin Liu and Kimberly D. Ritola and Derek Chiang and Sharon L. Campbell and Keith Burridge and Channing J Der},
  journal={The Journal of biological chemistry},
  volume={275 14},
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to cells of hematopoietic origin, Vav2 is widely expressed. Although Vav and Vav2 share highly related structural similarities and high sequence identity in their Dbl homology domains, it has been reported that they are active GEFs with distinct substrate specificities toward Rho family members. Whereas Vav displayed GEF… CONTINUE READING
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