Vav1: a hematopoietic signal transduction molecule involved in human malignancies.

  title={Vav1: a hematopoietic signal transduction molecule involved in human malignancies.},
  author={Shulamit Katzav},
  journal={The international journal of biochemistry & cell biology},
  volume={41 6},
Vav1 encodes a unique protein with several motifs known to play a role in tyrosine mediated signal transduction, including a DBL homology (DH) domain, a pleckstrin homology (PH) domain, a Src homology 2 (SH2) domain, and two Src homology 3 (SH3) domains. Physiological Vav1 expression is restricted to the hematopoietic system, where it functions primarily as a specific GDP/GTP nucleotide exchange factor (GEF), a function strictly regulated by tyrosine phosphorylation. In hematopoietic cells… CONTINUE READING


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