Vav proteins, masters of the world of cytoskeleton organization.

@article{Hornstein2004VavPM,
  title={Vav proteins, masters of the world of cytoskeleton organization.},
  author={Idit Hornstein and Andr{\'e}s Alcover and Shulamit Katzav},
  journal={Cellular signalling},
  year={2004},
  volume={16 1},
  pages={1-11}
}
Vav proteins are evolutionarily conserved from nematodes to mammals and play a pivotal role in many aspects of cellular signaling, coupling cell surface receptors to various effectors functions. In mammals, there are three family members; Vav1 is specifically expressed in the hematopoietic system, whereas Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain multiple domains that enable their function in various fashions. The participation of the Vav proteins in several processes… CONTINUE READING