Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin‐6

@article{Lee1997VavIA,
  title={Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin‐6},
  author={Ihn-Sook Lee and Yin Liu and Masashi Narazaki and Masahiko Hibi and Tadamitsu Kishimoto and Tetsuya Taga},
  journal={FEBS Letters},
  year={1997},
  volume={401}
}

Vav modulation of the Ras / MEK / ERK signaling pathway plays a role in NFAT activation and CD69 up‐regulation

Ras functions as an important downstream target of Vav in signaling pathways that lead to NFAT and ERK activation, and to CD69 expression, which indicates that Vav mediates some Ras‐dependent, but Rac‐independent, functions in T cells.

Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation

It is concluded that Vav3 mediates RPTK signaling and regulates GTPase activity, its native and mutant forms are able to modulate cell morphology, and it has the potential to induce cell transformation.

Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1

The cyclin-dependent kinase inhibitor p27/Kip1 is identified as a novel target to be regulated by IL-6-type cytokines and Stimulation-dependent upregulation of p27 mRNA occurred STAT3-dependently.

Analysis of IL-6-mediated growth control of myeloma cells using a gp130 chimeric receptor approach

Although the results suggest that STAT activation is crucial in gp130-mediated proliferation of myeloma cells, these results must be interpreted with caution given the demonstration of the interaction between chimeric and endogenous receptors in myel cancer cells.

Transactivation of gp130 in Myeloma Cells 1

The ability of IFN-α to transactivate gp130 in myeloma cells is revealed for the first time and transactivation of gp130 was critically dependent upon Janus Kinase activation by the initiating receptor and correlated with rapid and sustained Janus kinase 1 and tyrosine kinase (Tyk) 2 tyrosin phosphorylation.

Vav1 promotes lung cancer growth by instigating tumor-microenvironment cross-talk via growth factor secretion

Vav1 is a signal transducer that functions as a scaffold protein and a regulator of cytoskeleton organization in the hematopoietic system, where it is exclusively expressed. Recently, Vav1 was shown

The phosphatidylinositol 3-kinase/AKT kinase pathway in multiple myeloma plasma cells: roles in cytokine-dependent survival and proliferative responses.

A role for the PI 3-K/AKT pathway in cytokine-dependent responses in myeloma cells, which is independent of any activation of the ERK pathway, is supported.

Vav1 Promotes B-Cell Lymphoma Development

The results suggest a potential cross-talk between epithelial cells expressing Vav1, that secrete CSF-1, and the lymphocytes that express CSf-1R, thus leading to the generation of B-cell lymphomas, a novel mechanism by which Vav 1 contributes to tumor propagation.

Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses

Although the level of AKT activation can regulate sensitivity to dexamethasone-induced apoptosis, additional cytokine-induced AKT-independent pathways can mediate IL-6 protection against dexamETHasone.

References

Onco - gene 9 , 1917 - 1923

  • 1994