Vav-family proteins in T-cell signalling.

  title={Vav-family proteins in T-cell signalling.},
  author={Victor L. J. Tybulewicz},
  journal={Current opinion in immunology},
  volume={17 3},
The Vav family proteins (Vav1, Vav2, Vav3) are cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho-family GTPases. T-cell antigen receptor (TCR) signalling results in the tyrosine phosphorylation of Vav proteins and hence their activation. Results from mice deficient in one or more Vav proteins has shown that they play critical roles in T-cell development and activation. Vav1 is required for TCR-induced calcium flux, activation of the ERK MAP kinase pathway, activation of the NF… CONTINUE READING
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