Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity
@article{Berger2008VaultsAT, title={Vaults and the major vault protein: Novel roles in signal pathway regulation and immunity}, author={Walter Berger and Elisabeth Steiner and Michael Grusch and Leonilla Elbling and Michael Micksche}, journal={Cellular and Molecular Life Sciences}, year={2008}, volume={66}, pages={43-61} }
Abstract.The unique and evolutionary highly conserved major vault protein (MVP) is the main component of ubiquitous, large cellular ribonucleoparticles termed vaults. The 100 kDa MVP represents more than 70% of the vault mass which contains two additional proteins, the vault poly (ADP-ribose) polymerase (vPARP) and the telomerase-associated protein 1 (TEP1), as well as several short untranslated RNAs (vRNA). Vaults are almost ubiquitously expressed and, besides chemotherapy resistance, have…
185 Citations
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The high resolution, crystal structure of the of the seven N-terminal domains of MVP, forming the central vault barrel, revealed the interactions governing vault association and suggested a pH-dependent mechanism for a reversible dissociation induced by low pH.
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These findings show that RNAs can act as riboregulators of biological processes by interacting with proteins, and assign a function to a vault RNA.
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The crystal structure of the vault particle solved at 8 Å resolution, together with the 7 N‐terminal domains of MVP, reveal the interactions governing vault association and provide an explanation for a reversible dissociation induced by low pH.
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- BiologybioRxiv
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Vault RNAs are largely unknown and their molecular role is still under investigation, but their involvement in cellular mechanisms are summarized.
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The regulatory mechanism of MAPK signaling in synaptogenesis by vtRNAs is introduced and the possibility as a novel molecular basis for synapse formation is discussed.
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MVP represents a versatile platform for regulation of cellular signaling and survival and is a potential therapeutic target for modulation of resistance to apoptosis, implicated in aging modulation and cancer treatment.
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