Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line

@article{Ohguchi2005VaticanolCC,
  title={Vaticanol C-Induced Cell Death Is Associated with Inhibition of Pro-Survival Signaling in HL60 Human Leukemia Cell Line},
  author={K. Ohguchi and Y. Akao and K. Matsumoto and T. Tanaka and T. Ito and Munekazu Iinuma and Y. Nozawa},
  journal={Bioscience, Biotechnology, and Biochemistry},
  year={2005},
  volume={69},
  pages={353 - 356}
}
  • K. Ohguchi, Y. Akao, +4 authors Y. Nozawa
  • Published 2005
  • Medicine, Biology
  • Bioscience, Biotechnology, and Biochemistry
  • Recently, we found that vaticanol C (a resveratrol tetramer), which was isolated from stem bark of Dipterocarpaceae, exhibited growth suppression and induction of apoptosis via the loss of mitochondrial membrane potential and consequent caspases activation. The detailed mechanisms are not clearly understood. We decided to attempt to gain further insight into the mechanisms underlying vaticanol C-induced apoptosis in HL-60 cells. Treatment of HL-60 cells with vaticanol C was found to cause a… CONTINUE READING
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