Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo

@article{Tsukamoto2010VaticanolCA,
  title={Vaticanol C, a resveratrol tetramer, activates PPAR$\alpha$ and PPAR$\beta$/$\delta$ in vitro and in vivo},
  author={Tomoko Tsukamoto and Rieko Nakata and Emi Tamura and Yukiko Kosuge and Aya Kariya and Michiko Katsukawa and Satoshi Mishima and Tetsuro Ito and Munekazu Iinuma and Yukihiro Akao and Yoshinori Nozawa and Yuji Arai and Shobu Namura and Hiroyasu Inoue},
  journal={Nutrition \& Metabolism},
  year={2010},
  volume={7},
  pages={46 - 46}
}
BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial components contained in red wine, and also developed as a drug candidate. We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPARα-dependent mechanism. Here we report the different effects of the oligomers of resveratrol.MethodsWe evaluated the… 
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