Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo

@article{Tsukamoto2010VaticanolCA,
  title={Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo},
  author={Tomoko Tsukamoto and R. Nakata and Emi Tamura and Y. Kosuge and Aya Kariya and Michiko Katsukawa and S. Mishima and T. Ito and Munekazu Iinuma and Y. Akao and Y. Nozawa and Y. Arai and S. Namura and H. Inoue},
  journal={Nutrition & Metabolism},
  year={2010},
  volume={7},
  pages={46 - 46}
}
  • Tomoko Tsukamoto, R. Nakata, +11 authors H. Inoue
  • Published 2010
  • Medicine
  • Nutrition & Metabolism
  • BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial components contained in red wine, and also developed as a drug candidate. We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPARα-dependent mechanism. Here we report the different effects of the oligomers of resveratrol.MethodsWe evaluated the… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor α in mice
    • 215
    • Highly Influential
    Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression[S]
    • 177
    • PDF
    Sirt1 protects against high-fat diet-induced metabolic damage
    • 787
    • PDF
    Resveratrol improves health and survival of mice on a high-calorie diet
    • 3,775
    • PDF
    Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
    • 581
    SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
    • 782
    • PDF
    Therapeutic potential of resveratrol: the in vivo evidence
    • 3,074
    • PDF
    Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
    • 3,374
    • PDF
    Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome
    • 723
    • PDF
    Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.
    • 657