Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo

  title={Vaticanol C, a resveratrol tetramer, activates PPAR$\alpha$ and PPAR$\beta$/$\delta$ in vitro and in vivo},
  author={Tomoko Tsukamoto and Rieko Nakata and Emi Tamura and Yukiko Kosuge and Aya Kariya and Michiko Katsukawa and Satoshi Mishima and Tetsuro Ito and Munekazu Iinuma and Yukihiro Akao and Yoshinori Nozawa and Yuji Arai and Shobu Namura and Hiroyasu Inoue},
  journal={Nutrition \& Metabolism},
  pages={46 - 46}
BackgroundAppropriate long-term drinking of red wine is associated with a reduced risk of cardiovascular disease. Resveratrol, a well-known SIRT1 activator is considered to be one of the beneficial components contained in red wine, and also developed as a drug candidate. We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPARα-dependent mechanism. Here we report the different effects of the oligomers of resveratrol.MethodsWe evaluated the… 
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ε-Viniferin, a resveratrol dimer, prevents diet-induced obesity in mice.
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Recent advances in the study on resveratrol.
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A review of the studies on resveratrol, especially with respect to cyclooxygenase, peroxisome proliferator-activated receptor (PPAR), and endothelial nitric oxide synthase, and discuss their association with reduced risk for cardiovascular disease.
Resveratrol and Its Metabolites Bind to PPARs
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Carvacrol, a component of thyme oil, activates PPARα and γ and suppresses COX-2 expression[S]
It is shown that COX-2 promoter activity was suppressed by essential oils derived from thyme, clove, rose, eucalyptus, fennel, and bergamot in cell-based transfection assays using bovine arterial endothelial cells, suggesting that carvacrol regulates COx-2 expression through its agonistic effect on PPARγ.
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It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.
Its strong anti-inflammatory activity and the plausible mechanisms of these effects are reviewed to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan.
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
It is concluded that SRT1720, its structurally related compounds SRT2183 and SRT1460, and resveratrol are not direct activators of SIRT1, which exhibits multiple off-target activities against receptors, enzymes, transporters, and ion channels.
Therapeutic potential of resveratrol: the in vivo evidence
A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.
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