Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation

@article{Shibata2007VaticanolCA,
  title={Vaticanol C, a novel resveratrol tetramer, reduces lymph node and lung metastases of mouse mammary carcinoma carrying p53 mutation},
  author={M. Shibata and Y. Akao and Eiko Shibata and Y. Nozawa and T. Ito and S. Mishima and J. Morimoto and Y. Otsuki},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2007},
  volume={60},
  pages={681-691}
}
  • M. Shibata, Y. Akao, +5 authors Y. Otsuki
  • Published 2007
  • Biology, Medicine
  • Cancer Chemotherapy and Pharmacology
  • PurposeThe effects of vaticanol C (Vat-C), a novel resveratrol tetramer, were studied in a mouse metastatic mammary cancer model carrying mutations in p53 that produce a metastatic spectrum similar to that seen in human breast cancers.MethodsMammary tumors, induced by inoculation of syngeneic BALB/c mice with BJMC3879 cells, were subsequently treated with Vat-C at 0, 100 and 200 ppm in their diet.ResultsThe in vitro study demonstrated that Vat-C induced apoptosis, as inferred by morphological… CONTINUE READING
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